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Download Advances in Comparative and Environmental Physiology by S. H. Wright (auth.) PDF

By S. H. Wright (auth.)

Advances in Comparative and Environmental Physiology offers accomplished, built-in stories giving sound, serious, and provocative summaries of our current wisdom in environmental and comparative body structure, from the molecular to the organismic point. the sphere has now won the foreign prestige it merits and the association of a sequence dedicated to it's very well timed in view of its real speedy improvement. Biologists, physiologists, and biochemists, independently in their uncomplicated medical orientation, will locate this new sequence of significant interest.

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In: Florkin M, Scheer BT (eds) Chemical zoology, vol 1t. Academic Press, London New York, pp 1-47 A10ia RC, Augee ML, Orr GR, Raison JK (1986) A critical role for membranes in hibernation. In: Helier HC, Musacchia XJ, Wang LCH (eds) Living in the cold. Elsevier, Amsterdam New York, pp 19-26 Augee ML, Pehowich DJ, Raison JK, Wang LCH (1984) Seasonal and temperature-related changes in mitochondrial membranes associated with torpor in the mammalian hibernator, Spermophilus richardsonii. Biochim Biophys Acta 776:27 - 36 Baumber J, Denyes A (1963) Acetate-1)4C metabolism of white fat from ham§ters in cold exposure and hibernation.

1981). In the arctic ground squirrel (Fedotcheva et al. 1984), a rotenone, antimycin-insensitive pathway in liver mitochondria for the oxidation of NADH exists only in the hibernating state. The functional significance of this pathway is thought to provide an alternate means for the continuing production of NAD, which is needed for gluconeogenesis during hibernation, when NADH from lipolysis cannot be sufficiently oxidized by the normal mitochondrial respiratory chain due to inhibition of the dehydrogenase by low body temperature (Fedotcheva et al.

This may be a difficulty to resolve if the bioactive substance is tightly bound to serum albumin during deep hibernation and cannot be easily separated or transported across the placenta. Because of these apparent differences in basic characteristics in the nature and mode of action both series of studies claim to be studying the same HIT molecule, however, there exists the possibility that two different (or more) kinds of molecules are actually being investigated. Whether these molecules share similar or different physiological or pharmacological effects in the recipient is an open question and can only be Mammalian Hibernation: An Escape from the Cold 37 answered when the purified substances are chemically characterized and systematically tested.

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