By V. I. Ivanov, N. A. Liapunova (auth.), Professor Dr. Günter Obe (eds.)
Utilized genetic learn, genetic toxicology and mutation learn examine the mutagenicity and cancerogenicity of chemical substances and different brokers. everlasting mutation in genes and chromosomes, might be precipitated via aplethora of brokers, together with ionizing and nonionizing radiations, chemical compounds, and viruses. one of the points discused via Advances in Mutagenesis learn are (1) the certainty of the molecular mechanisms resulting in mutations, and (2) the prevention of a inconsiderate advent of mutagenic brokers into the surroundings. Contents: Nikolay W. Timofeeff-Ressovsky (1900-1981): An Essay on his existence and medical Achievements. - Arylnitrenium Ions and the Genotoxic efficiency of fragrant Amines and Nitro Compounds. - Analysisof Mutagenicity and Chemical constitution in quite a few sequence of similar Compounds. - Formation of 8-Hydroxyguanine by means of Oxidative DNA harm, its fix and its Mutagenic results. - Exploring Genetic and Non-Genetic Relationships: The Induction of Micronuclei. - Mechanisms of brought on Mutagenesis through Ultraviolet gentle in Escherichia coli. - Polytene Chromosomes in Mutagenesis. Three-Way Differential Stainingof Chromosomes for the identity of SCEs in step with mobile Cycle: basics and functions. - The Mammalian Centromere: Centromere Separation, Kinetochore Proteins and Aneuploidy. - Chorionic Villi research. - ExploringGenetic and Non-Genetic Relationships: The Induction of Micronuclei.
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Gann 75:1037-1039 Kasai H, Crain PF, Kuchino Y, Nishimura S, Ootsuyama A, Tanooka H (1986) Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis 7:1849-1851 Kasai H, Nishimura S, Kurokawa Y, Hayashi H (1987a) Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA. Carcinogenesis 8:1959-1961 Kasai H, Nishimura S, Toriumi Y, Itai T, Iitaka Y (1987b) The crystal structure of 9-ethyl-8hydroxyguanine.
Carcinogenesis 11:345-347 Wood ML, Dizdaroglu M, Gajewski E, Essigmann JM (1990) Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8oxoguanine) residue inserted at a unique site in a viral genome. Biochemistry 29:7024-7032 Yamamoto F, Kasai H, Chung MH, Ohtsuka E, Hori T, Nishimura S (1992) Ubiquitous presence in mammalian cells of enzymatic activity specifically cleaving 8-hydroxyguanine containing DNA. Jpn J Cancer Res (in press) Yanofsky C, Cox EC, Horn V (1966) The unusual mutagenic specificity of an E.
64 2 1 Introduction The interphase of genetics and carcinogenesis has been a field of active investigation ever since the realization that mutagenicity, or more precisely the ability to alter DNA, could be the basis of cancer causation. Indeed, this realization, which ultimately led to the "carcinogens are mutagens" paradigm (Ames et al. 1973), also spawned the field of genetic toxicology. Of course, the "somatic mutation theory of cancer causation" as well as the "electrophilic theory of carcinogenesis" (Miller and Miller 1977) received confirmation by the recognition of the role in carcinogenesis of the activation of proto-oncogenes and the deactivation of suppressor genes by mutagenic mechanisms.